Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers.

ABSTRACT:

Introduction

Cancer is often suggested to result from development gone awry. Links between normal embryonic development and cancer biology have been postulated, but no defined genetic basis has been established. We recently published the first transcriptomic analysis of embryonic mammary cell populations. Embryonic mammary epithelial cells are an immature progenitor cell population, lacking differentiation markers, which is reflected in their very distinct genetic profiles when compared with those of their postnatal descendents.

Methods

We defined an embryonic mammary epithelial signature that incorporates the most highly expressed genes from embryonic mammary epithelium when compared with the postnatal mammary epithelial cells. We looked for activation of the embryonic mamm

SUBMITTER: Zvelebil M 

PROVIDER: S-EPMC3672751 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature