Exercise attenuates PCB-induced changes in the mouse gut microbiome.

ABSTRACT:

Background

The gut microbiome, a dynamic bacterial community that interacts with the host, is integral to human health because it regulates energy metabolism and immune functions. The gut microbiome may also play a role in risks from environmental toxicants.

Objectives

We investigated the effects of polychlorinated biphenyls (PCBs) and exercise on the composition and structure of the gut microbiome in mice.

Methods

After mice exercised voluntarily for 5 weeks, they were treated by oral gavage with a mixture of environmentally relevant PCB congeners (PCB153, PCB138, and PCB180; total PCB dose, 150 µmol/kg) for 2 days. We then assessed the microbiome by determination of 16S rRNA using microarray analysis.

Results

Oral exposure to PCBs significantly altered the ab

SUBMITTER: Choi JJ 

PROVIDER: S-EPMC3672930 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature