Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock.

ABSTRACT:

Background

We sought to compare the association of whole-blood lactate kinetics with survival in patients with septic shock undergoing early quantitative resuscitation.

Methods

This was a preplanned analysis of a multicenter, ED-based, randomized, controlled trial of early sepsis resuscitation. Inclusion criteria were suspected infection, two or more systemic inflammation criteria, either systolic BP< 90 mm Hg after a fluid bolus or lactate level > 4 mM, two serial lactate measurements, and an initial lactate level > 2.0 mM. We calculated the relative lactate clearance, rate of lactate clearance, and occurrence of early lactate normalization (decline to < 2.0 mM in the first 6 h). Area under the receiver operating characteristic curve (AUC) and multivariate logis

SUBMITTER: Puskarich MA 

PROVIDER: S-EPMC3673659 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature