Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes.

ABSTRACT:

Background

CT scanning is increasingly used to characterize COPD. Although it is possible to obtain CT scan-measured lung lobe volumes, normal ranges remain unknown. Using COPDGene data, we developed reference equations for lobar volumes at maximal inflation (total lung capacity [TLC]) and relaxed exhalation (approximating functional residual capacity [FRC]).

Methods

Linear regression was used to develop race-specific (non-Hispanic white [NHW], African American) reference equations for lobar volumes. Covariates included height and sex. Models were developed in a derivation cohort of 469 subjects with normal pulmonary function and validated in 546 similar subjects. These cohorts were combined to produce final prediction equations, which were applied to 2,191 subjects with old

SUBMITTER: Come CE 

PROVIDER: S-EPMC3673661 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature