T cells localized to the androgen-deprived prostate are TH1 and TH17 biased.

ABSTRACT:

Background

T cells infiltrate the prostates of prostate cancer patients undergoing neoadjuvant androgen deprivation. These prostate-infiltrating T cells have an oligoclonal phenotype, suggesting the development of an antigen-specific T-cell response. We hypothesized that androgen deprivation might elicit a prostate tissue-specific T-cell response that could potentially be combined with other immune-active therapies, and consequently sought to investigate the nature and timing of this T-cell response following castration.

Methods

We investigated the phenotype and cytokine expression of T cells at various time points in the prostates of Lewis rats following surgical castration, and used adoptive transfer of prostate-infiltrating lymphocytes (PILs) to determine whether the infi

SUBMITTER: Morse MD 

PROVIDER: S-EPMC3673717 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature