Conductance-Based Determination of Solid-State Nanopore Size and Shape: An Exploration of Performance Limits.

ABSTRACT: Knowledge of nanopore size and shape is critical for many implementations of these single-molecule sensing elements. Geometry determination by fitting the electrolyte-concentration-dependence of the conductance of surface-charged, solid-state nanopores has been proposed to replace demanding electron microscope-based methods. The functional form of the conductance poses challenges for this method by restricting the number of free parameters used to characterize the nanopore. We calculated the electrolyte-dependent conductance of nanopores with an exponential-cylindrical radial profile using three free geometric parameters; this profile, itself, could not be uniquely geometry-optimized by the conductance. Several different structurally simplified models, however, generated quantitative agree

SUBMITTER: Frament CM 

PROVIDER: S-EPMC3673737 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature