Targeted delivery of siRNA-generating DNA nanocassettes using multifunctional nanoparticles.

ABSTRACT: Molecular therapy using a small interfering RNA (siRNA) has shown promise in the development of novel therapeutics. Various formulations have been used for in vivo delivery of siRNAs. However, the stability of short double-stranded RNA molecules in the blood and efficiency of siRNA delivery into target organs or tissues following systemic administration have been the major issues that limit applications of siRNA in human patients. In this study, multifunctional siRNA delivery nanoparticles are developed that combine imaging capability of nanoparticles with urokinase plasminogen activator receptor-targeted delivery of siRNA expressing DNA nanocassettes. This theranostic nanoparticle platform consists of a nanoparticle conjugated with targeting ligands and double-stranded DNA nanocassettes c

SUBMITTER: Cho YS 

PROVIDER: S-EPMC3674124 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature