Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors.

ABSTRACT: A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors.

SUBMITTER: Martin DP 

PROVIDER: S-EPMC3674230 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature