Association between physical activity and urinary estrogens and estrogen metabolites in premenopausal women.

ABSTRACT:

Objective

The objective of the study was to evaluate in premenopausal women the relationships of physically active and sedentary behaviors reported for adulthood and adolescence with a comprehensive profile of estrogen metabolism.

Methodology

Fifteen estrogens and estrogen metabolites (jointly termed EM) were measured using liquid chromatography-tandem mass spectrometry in luteal phase urines from 603 premenopausal women in the Nurses' Health Study II. Geometric means of individual EM, metabolic pathway groups, and pathway ratios were examined by level of exposure after adjustment for age, body mass index, alcohol intake, menstrual cycle length, and sample collection timing.

Results

High overall physical activity in adulthood (42+ metabolic equivalent h/wk vs. <3 meta

SUBMITTER: Matthews CE 

PROVIDER: S-EPMC3674291 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature