White paper: landscape on technical and conceptual requirements and competence framework in drug/disease modeling and simulation.

ABSTRACT: Pharmaceutical sciences experts and regulators acknowledge that pharmaceutical development as well as drug usage requires more than scientific advancements to cope with current attrition rates/therapeutic failures. Drug disease modeling and simulation (DDM&S) creates a paradigm to enable an integrated and higher-level understanding of drugs, (diseased)systems, and their interactions (systems pharmacology) through mathematical/statistical models (pharmacometrics)(1)-hence facilitating decision making during drug development and therapeutic usage of medicines. To identify gaps and challenges in DDM&S, an inventory of skills and competencies currently available in academia, industry, and clinical practice was obtained through survey. The survey outcomes revealed benefits, weaknesses, and hurd

SUBMITTER: Vlasakakis G 

PROVIDER: S-EPMC3674326 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature