Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences.

ABSTRACT: The Afrotropical mosquito Anopheles gambiae sensu stricto, a major vector of malaria, is currently undergoing speciation into the M and S molecular forms. These forms have diverged in larval ecology and reproductive behavior through unknown genetic mechanisms, despite considerable levels of hybridization. Previous genome-wide scans using gene-based microarrays uncovered divergence between M and S that was largely confined to gene-poor pericentromeric regions, prompting a speciation-with-ongoing-gene-flow model that implicated only about 3% of the genome near centromeres in the speciation process. Here, based on the complete M and S genome sequences, we report widespread and heterogeneous genomic divergence inconsistent with appreciable levels of interform gene flow, suggesting a more advan

SUBMITTER: Lawniczak MK 

PROVIDER: S-EPMC3674514 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature