Impact of natural genetic variation on gene expression dynamics.

ABSTRACT: DNA sequence variation causes changes in gene expression, which in turn has profound effects on cellular states. These variations affect tissue development and may ultimately lead to pathological phenotypes. A genetic locus containing a sequence variation that affects gene expression is called an "expression quantitative trait locus" (eQTL). Whereas the impact of cellular context on expression levels in general is well established, a lot less is known about the cell-state specificity of eQTL. Previous studies differed with respect to how "dynamic eQTL" were defined. Here, we propose a unified framework distinguishing static, conditional and dynamic eQTL and suggest strategies for mapping these eQTL classes. Further, we introduce a new approach to simultaneously infer eQTL from different ce

SUBMITTER: Ackermann M 

PROVIDER: S-EPMC3674999 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature