Divergent cellular pathways of hippocampal memory consolidation and reconsolidation.

ABSTRACT: The reconsolidation of memories after their retrieval involves cellular mechanisms that recapitulate much of the initial consolidation process. However, we have previously demonstrated that there are independent cellular mechanisms of consolidation and reconsolidation in the dorsal hippocampus for contextual fear memories. Expression of BDNF was required for consolidation, while Zif268 expression was necessary for reconsolidation. Given the dichotomy between the obvious mechanistic similarity and notable dissociations between consolidation and reconsolidation, we sought to determine whether the separation at the level of gene expression reflected either parallel and independent upstream signaling pathways, or common upstream mechanisms that diverge by the level of transcriptional activatio

SUBMITTER: Lee JL 

PROVIDER: S-EPMC3675315 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature