Sequence features of yeast and human core promoters that are predictive of maximal promoter activity.

ABSTRACT: The core promoter is the region in which RNA polymerase II is recruited to the DNA and acts to initiate transcription, but the extent to which the core promoter sequence determines promoter activity levels is largely unknown. Here, we identified several base content and k-mer sequence features of the yeast core promoter sequence that are highly predictive of maximal promoter activity. These features are mainly located in the region 75 bp upstream and 50 bp downstream of the main transcription start site, and their associations hold for both constitutively active promoters and promoters that are induced or repressed in specific conditions. Our results unravel several architectural features of yeast core promoters and suggest that the yeast core promoter sequence downstream of the TATA box (

SUBMITTER: Lubliner S 

PROVIDER: S-EPMC3675475 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature