Thymic malignancies: from clinical management to targeted therapies.

ABSTRACT:

Purpose

A key challenge in the treatment of thymoma and thymic carcinoma (TC) is in improving our understanding of the molecular biology of these relatively rare tumors. In recent years, significant efforts have been made to dissect the molecular pathways involved in their carcinogenesis. Here we discuss the results of large-scale genomic analyses conducted to date and review the most active chemotherapies and targeted treatments.

Methods

We reviewed the literature for chemotherapeutic trials in the last 20 years and trials involving targeted therapies between 1999 and 2010. The search was supplemented by a review of abstracts presented at the annual meetings of the American Society of Clinical Oncology (from 1999 to 2010), at the first International Conference on Thymic Mal

SUBMITTER: Kelly RJ 

PROVIDER: S-EPMC3675690 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature