Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial.

ABSTRACT:

Purpose

Estrogens and androgens are elevated in obesity and associated with increased postmenopausal breast cancer risk, but the effect of weight loss on these biomarkers is unknown. We evaluated the individual and combined effects of a reduced-calorie weight loss diet and exercise on serum sex hormones in overweight and obese postmenopausal women.

Patients and methods

We conducted a single-blind, 12-month, randomized controlled trial from 2005 to 2009. Participants (age 50 to 75 years; body mass index > 25.0 kg/m(2), exercising < 100 minutes/wk) were randomly assigned using a computer-generated sequence to (1) reduced-calorie weight loss diet ("diet"; n = 118), (2) moderate- to vigorous-intensity aerobic exercise ("exercise"; n = 117), (3) combined reduced-calorie weight lo

SUBMITTER: Campbell KL 

PROVIDER: S-EPMC3675691 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature