Proteome-wide prediction of self-interacting proteins based on multiple properties.

ABSTRACT: Self-interacting proteins, whose two or more copies can interact with each other, play important roles in cellular functions and the evolution of protein interaction networks (PINs). Knowing whether a protein can self-interact can contribute to and sometimes is crucial for the elucidation of its functions. Previous related research has mainly focused on the structures and functions of specific self-interacting proteins, whereas knowledge on their overall properties is limited. Meanwhile, the two current most common high throughput protein interaction assays have limited ability to detect self-interactions because of biological artifacts and design limitations, whereas the bioinformatic prediction method of self-interacting proteins is lacking. This study aims to systematically study and pr

SUBMITTER: Liu Z 

PROVIDER: S-EPMC3675823 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature