Replication and immunogenicity of swine, equine, and avian h3 subtype influenza viruses in mice and ferrets.

ABSTRACT: Since it is difficult to predict which influenza virus subtype will cause an influenza pandemic, it is important to prepare influenza virus vaccines against different subtypes and evaluate the safety and immunogenicity of candidate vaccines in preclinical and clinical studies prior to a pandemic. In addition to infecting humans, H3 influenza viruses commonly infect pigs, horses, and avian species. We selected 11 swine, equine, and avian H3 influenza viruses and evaluated their kinetics of replication and ability to induce a broadly cross-reactive antibody response in mice and ferrets. The swine and equine viruses replicated well in the upper respiratory tract of mice. With the exception of one avian virus that replicated poorly in the lower respiratory tract, all of the viruses replicated

SUBMITTER: Baz M 

PROVIDER: S-EPMC3676140 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature