Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy.

ABSTRACT:

Purpose

Increase in reactive oxygen species (ROS) is one of the major retinal metabolic abnormalities associated with the development of diabetic retinopathy. NF-E2-related factor 2 (Nrf2), a redox sensitive factor, provides cellular defenses against the cytotoxic ROS. In stress conditions, Nrf2 dissociates from its cytosolic inhibitor, Kelch like-ECH-associated protein 1 (Keap1), and moves to the nucleus to regulate the transcription of antioxidant genes including the catalytic subunit of glutamylcysteine ligase (GCLC), a rate-limiting reduced glutathione (GSH) biosynthesis enzyme. Our aim is to understand the role of Nrf2-Keap1-GCLC in the development of diabetic retinopathy.

Methods

Effect of diabetes on Nrf2-Keap1-GCLC pathway, and subcellular localization of Nrf2 and it

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC3676188 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature