Ontology highlight
ABSTRACT:
SUBMITTER: Lu W
PROVIDER: S-EPMC3676710 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Lu Wen W Fox Pangkong P Lakonishok Margot M Davidson Michael W MW Gelfand Vladimir I VI
Current biology : CB 20130523 11
Remarkably, forces within a neuron can extend its axon to a target that could be meters away. The two main cytoskeleton components in neurons are microtubules, which are mostly bundled along the axon shaft, and actin filaments, which are highly enriched in a structure at the axon distal tip, the growth cone. Neurite extension has been thought to be driven by a combination of two forces: pushing via microtubule assembly, and/or pulling by an actin-driven mechanism in the growth cone. Here we show ...[more]