Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC3676802 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Yang Yajun Y Xiu Jinghui J Liu Jiangning J Zhang Li L Li Xiaoying X Xu Yanfeng Y Qin Chuan C Zhang Lianfeng L
International journal of molecular sciences 20130503 5
Human enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. Presently, no vaccines or antiviral drugs have been clinically available to employ against EV71. In this study, we demonstrate that treatment with chebulagic acid reduced the viral cytopathic effect on rhabdomyosarcoma cells with an IC50 of 12.5 μg/mL. The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to effi ...[more]