Acute silent cerebral ischemic events in children with sickle cell anemia.

ABSTRACT:

Background

Irregular, sporadic episodes of ischemic brain injury are known to occur in sickle cell anemia (SCA), resulting in overt stroke and silent cerebral infarction. Ongoing ischemia in other organs is common in SCA but has never been documented in the brain.

Objective

To test the hypothesis that acute silent cerebral ischemic events (ASCIEs) are frequent and potentially transient.

Design

Cross-sectional and cohort study of children with SCA screened by magnetic resonance imaging (MRI) of the brain for a randomized clinical trial.

Setting

Clinical trial setting in tertiary care centers.

Patients

Asymptomatic children with SCA without known stroke, neurologic injury, or epilepsy not receiving treatment with transfusions or hydroxyurea.

Main outcom

SUBMITTER: Quinn CT 

PROVIDER: S-EPMC3677221 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature