Ontology highlight
ABSTRACT:
SUBMITTER: Singh D
PROVIDER: S-EPMC3677224 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20120726 6099
The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors examined) harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor (FGFR) genes (FGFR1 or FGFR3) to the transforming acidic coiled-coil (TACC) coding domains of TACC1 or TACC3, respectively. The FGFR-TACC fusion protein displays oncogenic activity when introduc ...[more]