RNAi pathways contribute to developmental history-dependent phenotypic plasticity in C. elegans.

ABSTRACT: Early environmental experiences profoundly influence adult phenotypes through complex mechanisms that are poorly understood. We previously showed that adult Caenorhabditis elegans that transiently passed through the stress-induced dauer larval stage (post-dauer adults) exhibit significant changes in gene expression profiles, chromatin states, and life history traits when compared with adults that bypassed the dauer stage (control adults). These wild-type, isogenic animals of equivalent developmental stages exhibit different signatures of molecular marks that reflect their distinct developmental trajectories. To gain insight into the mechanisms that contribute to these developmental history-dependent phenotypes, we profiled small RNAs from post-dauer and control adults by deep sequencing. R

SUBMITTER: Hall SE 

PROVIDER: S-EPMC3677242 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature