Survival is associated with genetic variation in inflammatory pathway genes among patients with resected and unresected pancreatic cancer.

ABSTRACT:

Objective

To test whether or not the association between inflammation and pancreatic ductal adenocarcinoma (PC) is facilitated by host susceptibility, specifically by genetic polymorphisms in inflammation-related genes.

Summary background data

Inflammation has been linked to PC. Reports have cited an increased expression of proinflammatory mediators, such as NF-κB and COX, in PC but not in normal adjacent tissue, suggesting a possible role in carcinogenesis. We sought to further understand the role that genetic variants in the NF-κB inflammatory pathway play in the development and progression of PC.

Methods

We genotyped 1536 tag single nucleotide polymorphisms (SNPs) in 102 candidate genes of multiple inflammatory pathways in 1308 white patients with PC who were divid

SUBMITTER: Reid-Lombardo KM 

PROVIDER: S-EPMC3677709 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature