Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.

ABSTRACT: A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors.

SUBMITTER: Raje M 

PROVIDER: S-EPMC3678123 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature