Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation.

ABSTRACT:

Context

KLLN is a newly identified gene with unknown function and shares a bidirectional promoter with PTEN.

Objective

The objective of the study was to analyze the relationship between KILLIN (KLLN) expression and prostate cancer and the potential tumor suppressive effect.

Design

We conducted an in silico analysis to compare KLLN expression in normal prostate and matched primary carcinoma tissues. We subsequently used immunohistochemistry to examine KLLN expression and association with Gleason grade and score in 109 prostatectomy samples. KLLN's tumor-suppressive effect was studied in androgen-dependent and androgen-independent cell models.

Patients

Patients were diagnosed with peripheral zone prostate carcinomas without metastasis at the time of prostatectomy

SUBMITTER: Wang Y 

PROVIDER: S-EPMC3678149 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature