Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population.

ABSTRACT: Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for pancreatic cancer (PC). We investigated the association of two single-nucleotide polymorphisms (SNPs) of the VDR gene with PC in age- and gender-matched patients and controls. PC (n=91) and healthy control (n=80) samples were genotyped for the FokI (rs2228570) and BsmI (rs1544410) polymorphisms using the PCR and restriction fragment length polymorphism (PCR-RFLP) method. Chi-square analysis was used to test for the overall association of VDR genotype with disease. There was a significant difference in the frequency of genotype FF between the PC patients and controls (P^trend=0.009); however, the difference in frequency of genotype BB between the two groups was not significant (P^trend

SUBMITTER: Li L 

PROVIDER: S-EPMC3678656 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature