Formal synthesis of (-)-agelastatin A: an iron(II)-mediated cyclization strategy.

ABSTRACT: An iron(II)-mediated aminohalogenation of a cyclopentenyl N-tosyloxycarbamate provided new access to the key intermediate for the synthesis of (-)-agelastatin A (AA, 1), a potent antiproliferative alkaloid. The present synthetic endeavour offered an insight into the mechanism underlying the iron(II)-mediated aminohalogenation of N-tosyloxycarbamate, in which the radical properties of the N-iron intermediates in the redox states were operative.

SUBMITTER: Shigeoka D 

PROVIDER: S-EPMC3678661 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature