Synaptic changes in the dentate gyrus of APP/PS1 transgenic mice revealed by electron microscopy.

ABSTRACT: Numerous studies have reported widespread synaptic dysfunction or loss in early stages of both Alzheimer disease (AD) patients and animal models; it is widely accepted that synapse loss is the major structural correlate of cognitive dysfunction. Elucidation of the changes that may affect synapses is crucial for understanding the pathogenic mechanisms underlying AD, but ultrastructural preservation of human postmortem brain tissue is often poor, and classical methods for quantification of synapses have significant technical limitations. We previously observed changes in dendritic spines in plaque-free regions of the neuropil of the dentate gyrus of double-transgenic APP/PS1 (amyloid precursor protein/presenilin 1) model mice by light microscopy. Here, we used electron microscopy to examine

SUBMITTER: Alonso-Nanclares L 

PROVIDER: S-EPMC3678882 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature