Endocytosis genes facilitate protein and membrane transport in C. elegans sensory cilia.

ABSTRACT:

Background

Multiple intracellular transport pathways drive the formation, maintenance, and function of cilia, a compartmentalized organelle associated with motility, chemo-/mechano-/photosensation, and developmental signaling. These pathways include cilium-based intraflagellar transport (IFT) and poorly understood membrane trafficking events. Defects in ciliary transport contribute to the etiology of human ciliary disease such as Bardet-Biedl syndrome (BBS). In this study, we employ the genetically tractable nematode Caenorhabditis elegans to investigate whether endocytosis genes function in cilium formation and/or the transport of ciliary membrane or ciliary proteins.

Results

Here we show that localization of the clathrin light chain, AP-2 clathrin adaptor, dynamin, and RAB

SUBMITTER: Kaplan OI 

PROVIDER: S-EPMC3678972 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature