Inflammation and resolution are associated with upregulation of fatty acid β-oxidation in Zymosan-induced peritonitis.

ABSTRACT: Inflammation is a fundamental defensive response to harmful stimuli. However, it can cause damage if it does not subside. To avoid such damage, organisms have developed a mechanism called resolution of inflammation. Here we applied an untargeted metabolomics approach to a sterile and self-resolving animal model of acute inflammation, namely zymosan-induced peritonitis in mice, to examine the effect of inflammation and resolution on the metabolomic profiles. Significant and time-dependent changes in metabolite profiles after zymosan administration were observed in both peritoneal wash fluid (PWF) and plasma. These metabolomic changes correlated well with inflammatory chemokine or cytokine production. In PWF, most of metabolites that could detected increased in zymosan-treated mice, which is

SUBMITTER: Fujieda Y 

PROVIDER: S-EPMC3679047 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature