A randomized clinical trial of trans-dermal nicotine replacement in pregnant African-American smokers.

ABSTRACT: We compared acceptability, adherence and efficacy of trans-dermal nicotine patches and cognitive behavioral therapy (Group 1) to cognitive behavioral therapy alone (Group 2) in minority pregnant smokers. This is a randomized controlled trial. 52 women were recruited during pregnancy with a mean gestational age 18.5 ± 5.0 weeks and followed through delivery. Randomization was by site and initial cotinine levels. Interventionists and interviewers were blinded to group assignment. Two different nicotine replacement therapy dosing regiments were administered according to the baseline salivary cotinine level. A process evaluation model summarized patient adherence. The main outcome measure was self-report of cessation since last visit, confirmed by exhaled carbon monoxide. Analyses of categoric

SUBMITTER: El-Mohandes AA 

PROVIDER: S-EPMC3679235 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature