Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes.

ABSTRACT: Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.

SUBMITTER: Schmidt SF 

PROVIDER: S-EPMC3679271 | biostudies-literature | 2012 Jan-Feb

REPOSITORIES: biostudies-literature