Identification of CAD candidate genes in GWAS loci and their expression in vascular cells.

ABSTRACT: Recent genome-wide association studies (GWAS) have identified 35 loci that significantly associate with coronary artery disease (CAD) susceptibility. The majority of the genes represented in these loci have not previously been studied in the context of atherosclerosis. To characterize the roles of these candidate genes in the vessel wall, we determined their expression levels in endothelial, smooth muscle, and macrophage cells isolated from healthy, prelesioned, and lesioned mouse aortas. We also performed expression quantitative locus (eQTL) mapping of these genes in human endothelial cells under control and proatherogenic conditions. Of the 57 genes studied, 31 were differentially expressed in one or more cell types in disease state in mice, and the expression levels of 8 were significan

SUBMITTER: Erbilgin A 

PROVIDER: S-EPMC3679391 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature