Genome-wide comparative analysis revealed significant transcriptome changes in mice after Toxoplasma gondii infection.

ABSTRACT:

Background

Toxoplasma gondii is an intracellular parasite that can modulate host responses and presumably host behavior. Host responses as well as pathogenesis vary depending on the parasite strains that are responsible for infection. In immune competent individuals, T. gondii preferentially infects tissues of the central nervous systems (CNS), which might be an additional factor in certain psychiatric disorders. While in immune-compromised individuals and pregnant women, the parasite can cause life-threatening infections. With the availability of the genome-wide investigation platform, the global responses in gene expression of the host after T. gondii infection can be systematically investigated.

Methods

Total RNA of brain tissues and peripheral lymphocytes of BALB/C mice

SUBMITTER: Jia B 

PROVIDER: S-EPMC3679772 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature