TIMPs of parasitic helminths - a large-scale analysis of high-throughput sequence datasets.

ABSTRACT:

Background

Tissue inhibitors of metalloproteases (TIMPs) are a multifunctional family of proteins that orchestrate extracellular matrix turnover, tissue remodelling and other cellular processes. In parasitic helminths, such as hookworms, TIMPs have been proposed to play key roles in the host-parasite interplay, including invasion of and establishment in the vertebrate animal hosts. Currently, knowledge of helminth TIMPs is limited to a small number of studies on canine hookworms, whereas no information is available on the occurrence of TIMPs in other parasitic helminths causing neglected diseases.

Methods

In the present study, we conducted a large-scale investigation of TIMP proteins of a range of neglected human parasites including the hookworm Necator americanus, the round

SUBMITTER: Cantacessi C 

PROVIDER: S-EPMC3679795 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature