Exploring the cooccurrence patterns of multiple sets of genomic intervals.

ABSTRACT:

Background

Exploring the spatial relationship of different genomic features has been of great interest since the early days of genomic research. The relationship sometimes provides useful information for understanding certain biological processes. Recent advances in high-throughput technologies such as ChIP-seq produce large amount of data in the form of genomic intervals. Most of the existing methods for assessing spatial relationships among the intervals are designed for pairwise comparison and cannot be easily scaled up.

Results

We present a statistical method and software tool to characterize the cooccurrence patterns of multiple sets of genomic intervals. The occurrences of genomic intervals are described by a simple finite mixture model, where each component represents

SUBMITTER: Wu H 

PROVIDER: S-EPMC3679813 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature