A novel method for cross-species gene expression analysis.

ABSTRACT:

Background

Analysis of gene expression from different species is a powerful way to identify evolutionarily conserved transcriptional responses. However, due to evolutionary events such as gene duplication, there is no one-to-one correspondence between genes from different species which makes comparison of their expression profiles complex.

Results

In this paper we describe a new method for cross-species meta-analysis of gene expression. The method takes the homology structure between compared species into account and can therefore compare expression data from genes with any number of orthologs and paralogs. A simulation study shows that the proposed method results in a substantial increase in statistical power compared to previously suggested procedures. As a proof of concep

SUBMITTER: Kristiansson E 

PROVIDER: S-EPMC3679856 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature