Modular, rule-based modeling for the design of eukaryotic synthetic gene circuits.

ABSTRACT:

Background

The modular design of synthetic gene circuits via composable parts (DNA segments) and pools of signal carriers (molecules such as RNA polymerases and ribosomes) has been successfully applied to bacterial systems. However, eukaryotic cells are becoming a preferential host for new synthetic biology applications. Therefore, an accurate description of the intricate network of reactions that take place inside eukaryotic parts and pools is necessary. Rule-based modeling approaches are increasingly used to obtain compact representations of reaction networks in biological systems. However, this approach is intrinsically non-modular and not suitable per se for the description of composable genetic modules. In contrast, the Model Description Language (MDL) adopted by the modeling

SUBMITTER: Marchisio MA 

PROVIDER: S-EPMC3680069 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature