In vivo microdamage is an indicator of susceptibility to initiation and propagation of microdamage in human femoral trabecular bone.

ABSTRACT: Microdamage has been cited as an important element of trabecular bone quality and fracture risk, as materials with flaws have lower modulus and strength than equivalent undamaged materials. However, the magnitude of the effect of damage on failure properties depends on its tendency to propagate. Human femoral trabecular bone from the neck and greater trochanter was subjected to one of compressive, torsional, or combined compression and torsion. The in vivo, new, and propagating damage were then quantified in thick sections under epifluorescent microscopy. Multiaxial loading, which was intended to represent an off-axis load such as a fall or accident, caused much more damage than either simple compression or shear, and similarly caused the greatest stiffness loss. In all cases, initiation o

SUBMITTER: Wu Z 

PROVIDER: S-EPMC3680136 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature