Microarray and deep sequencing cross-platform analysis of the mirRNome and isomiR variation in response to epidermal growth factor.

ABSTRACT:

Background

Epidermal Growth Factor (EGF) plays an important function in the regulation of cell growth, proliferation, and differentiation by binding to its receptor (EGFR) and providing cancer cells with increased survival responsiveness. Signal transduction carried out by EGF has been extensively studied at both transcriptional and post-transcriptional levels. Little is known about the involvement of microRNAs (miRNAs) in the EGF signaling pathway. miRNAs have emerged as major players in the complex networks of gene regulation, and cancer miRNA expression studies have evidenced a direct involvement of miRNAs in cancer progression.

Results

In this study, we have used an integrative high content analysis approach to identify the specific miRNAs implicated in EGF signaling in

SUBMITTER: Llorens F 

PROVIDER: S-EPMC3680220 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature