Potent anticancer activity of cystine-based dipeptides and their interaction with serum albumins.

ABSTRACT:

Background

Cancer is a severe threat to the human society. In the scientific community worldwide cancer remains a big challenge as there are no remedies as of now. Cancer is quite complicated as it involves multiple signalling pathways and it may be caused by genetic disorders. Various natural products and synthetic molecules have been designed to prevent cell proliferation. Peptide-based anticancer drugs, however, are not explored properly. Though peptides have their inherent proteolytic instability, they could act as anticancer agents.

Results

In this present communication a suitably protected cystine based dipeptide and its deprotected form have been synthesized. Potent anticancer activities were confirmed by MTT assay (a laboratory test and a standard colorimetric assay,

SUBMITTER: Banerji B 

PROVIDER: S-EPMC3680302 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature