Inhibition of HIV replication in vitro by clinical immunosuppressants and chemotherapeutic agents.

ABSTRACT:

Background

Recent studies have suggested that a functional cure for HIV-1 infection, purportedly resultant from allogeneic bone marrow transplantation, may be possible. Additionally, the first such patient was treated with whole-body irradiation, immunosuppressants, and the chemotherapeutic, cytarabine. However, the precise role of the coinciding medical interventions in diminishing detectable HIV reservoirs remains unstudied.

Findings

In this article, we demonstrate that the immunosuppressants, mycophenolic acid and cyclosporine, and the chemotherapeutic, cytarabine, are potent antiretroviral agents at clinically relevant dosages. These drugs strongly inhibit HIV-1 replication in a GFP indicator T cell line and peripheral blood mononuclear cells (PBMC).

Conclusions

O

SUBMITTER: Hawley T 

PROVIDER: S-EPMC3680316 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature