Ontology highlight
ABSTRACT:
SUBMITTER: Petry S
PROVIDER: S-EPMC3680348 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Cell 20130201 4
The microtubules that comprise mitotic spindles in animal cells are nucleated at centrosomes and by spindle assembly factors that are activated in the vicinity of chromatin. Indirect evidence has suggested that microtubules also might be nucleated from pre-existing microtubules throughout the spindle, but this process has not been observed directly. Here, we demonstrate microtubule nucleation from the sides of existing microtubules in meiotic Xenopus egg extracts. Daughter microtubules grow at a ...[more]