Characterizing genes with distinct methylation patterns in the context of protein-protein interaction network: application to human brain tissues.

ABSTRACT:

Background

DNA methylation is an essential epigenetic mechanism involved in transcriptional control. However, how genes with different methylation patterns are assembled in the protein-protein interaction network (PPIN) remains a mystery.

Results

In the present study, we systematically dissected the characterization of genes with different methylation patterns in the PPIN. A negative association was detected between the methylation levels in the brain tissues and topological centralities. By focusing on two classes of genes with considerably different methylation levels in the brain tissues, namely the low methylated genes (LMGs) and high methylated genes (HMGs), we found that their organizing principles in the PPIN are distinct. The LMGs tend to be the center of the PPIN, a

SUBMITTER: Li Y 

PROVIDER: S-EPMC3680465 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature