Oral but not intravenous glucose acutely decreases circulating interleukin-6 concentrations in overweight individuals.

ABSTRACT:

Background

Plasma interleukin-6 (IL-6) concentrations decrease acutely 1 h after ingestion of a glucose load or mixed meals and this may be mediated by an anti-inflammatory effect of insulin. The aim of the present study was to compare the effect of higher versus lower insulin levels on plasma IL-6 concentrations following oral compared with intravenous glucose administration in overweight/obese subjects.

Methods and findings

Fifteen subjects (12 women and 3 men) with BMI >28 kg/m(2) were given an oral glucose load (75 g) followed a week later by an intravenous infusion of glucose aimed at matching plasma glucose concentrations during the oral glucose load. A week later, they drank a volume of water equivalent to the volume consumed with the oral glucose load. Plasma glucose

SUBMITTER: Manning PJ 

PROVIDER: S-EPMC3680471 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature