Reciprocal regulation of NF-kB (Relish) and Subolesin in the tick vector, Ixodes scapularis.

ABSTRACT:

Background

Tick Subolesin and its ortholog in insects and vertebrates, Akirin, have been suggested to play a role in the immune response through regulation of nuclear factor-kappa B (NF-kB)-dependent and independent gene expression via interaction with intermediate proteins that interact with NF-kB and other regulatory proteins, bind DNA or remodel chromatin to regulate gene expression. The objective of this study was to characterize the structure and regulation of subolesin in Ixodes scapularis. I. scapularis is a vector of emerging pathogens such as Borrelia burgdorferi, Anaplasma phagocytophilum and Babesia microti that cause in humans Lyme disease, anaplasmosis and babesiosis, respectively. The genome of I. scapularis was recently sequenced, and this tick serves as a model orga

SUBMITTER: Naranjo V 

PROVIDER: S-EPMC3680474 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature