Gene expression is highly correlated on the chromosome level in urinary bladder cancer.

ABSTRACT:

Objective

Chromosome correlation maps display correlations between gene expression patterns on the same chromosome. Our goal was to map the genes on chromosome regions and to identify correlations through their location on chromosome regions.

Materials and methods

Following microarray analysis we used Ingenuity Pathway Analysis (IPA) to construct gene networks of the co-deregulated genes in bladder cancer. Chromosome mapping, mathematical modeling and data simulations were performed using the WebGestalt and Matlab(®) softwares.

Results

The top deregulated molecules among 129 bladder cancer samples were implicated in the PI3K/AKT signaling, cell cycle, Myc-mediated apoptosis signaling and ERK5 signaling pathways. Their most prominent molecular and cellular functions we

SUBMITTER: Lambrou GI 

PROVIDER: S-EPMC3680534 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature