Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples.

ABSTRACT:

Background

Meta-analysis of case-control genome-wide association studies (GWAS) for early onset and morbid obesity identified four variants in/near the PRL, PTER, MAF and NPC1 genes.

Objective

We aimed to validate association of these variants with obesity-related traits in population-based samples.

Design

Genotypes and anthropometric traits were available in up to 31 083 adults from the Fenland, EPIC-Norfolk, Whitehall II, Ely and Hertfordshire studies and in 2042 children and adolescents from the European Youth Heart Study. In each study, we tested associations of rs4712652 (near-PRL), rs10508503 (near-PTER), rs1424233 (near-MAF) and rs1805081 (NPC1), or proxy variants (r (2)>0.8), with the odds of being overweight and obese, as well as with body mass index (BMI), p

SUBMITTER: den Hoed M 

PROVIDER: S-EPMC3680864 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature